[CAS NO. 27750-13-6] (-)-Hydroxycitric acid lactone
PRODUCTS SPECIFICATIONS [27750-13-6]
DESCRIPTION [27750-13-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 190.11 |
| Molecular Formula | C6H6O7 |
| SMILES | O[C@](CC(O1)=O)(C(O)=O)[C@H]1C(O)=O |
Summary
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase . (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis [1] [2] .
In Vivo
(-)-Hydroxycitric acid lactone (1000-3000mg/kg; fed for a period of 4 weeks) significantly decreases body weight at 2000 and 3000 mg/kg in chicken [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 1-day-old male broiler chickens [2] |
| Dosage: | 1000, 2000, 3000 mg/kg |
| Administration: | Fed for a period of 4 weeks |
| Result: | Body weight and average daily gain (ADG) in the 2000 mg/kg and 3000 mg/kg were significantly lower. |
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 250 mg/mL ( 1315.03 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.2601 mL | 26.3006 mL | 52.6011 mL |
| 5 mM | 1.0520 mL | 5.2601 mL | 10.5202 mL |
| 10 mM | 0.5260 mL | 2.6301 mL | 5.2601 mL |
References
- [1] Jena BS, et al. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. J Agric Food Chem. 2002 Jan 2;50(1):10-22.
- [2] Han J, et al. (-)-Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related geneexpression in broiler chickens. Lipids Health Dis. 2016 Feb 24;15:37.