[CAS NO. 2785430-85-3] ALK5-IN-29
PRODUCTS SPECIFICATIONS [2785430-85-3]
DESCRIPTION [2785430-85-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 444.51 |
| Molecular Formula | C24H25FN8 |
| SMILES | CC1=CC=CC2=C(NC3=NC(NC4=CC(CN5CCNCC5)=CC(F)=C4)=NC=C3)C=NN=C12 |
Summary
IC50 & Target
IC50: ≤10 nM (ALK5/2); ≤100 nM (RD-SMAD receptor) [1]
In Vitro
ALK5-IN-29 (EX-06) has kinase inhibition of ALK5 with an IC
50
value of ≤10 nM
[1]
.
ALK5-IN-29 has kinase selectivity of ALK2/ALK5 with an IC
50
value of ≤10 nM
[1]
.
ALK5-IN-29 shows TGFB-RI inhibition (RD-SMAD receptor activity) with an IC
50
value of ≤100 nM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.