[CAS NO. 2799-07-7] S-Trityl-L-cysteine

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PRODUCTS SPECIFICATIONS [2799-07-7]

Catalog

HY-W011102

Brand

MCE

CAS

2799-07-7

DESCRIPTION [2799-07-7]

Overview

MDL	MFCD00002611
Molecular Weight	363.47
Molecular Formula	C22H21NO2S
SMILES	N[C@@H](CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C(O)=O

For research use only. We do not sell to patients.

Summary

S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC ₅₀ of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities ^[1] ^[2] .

IC50 & Target

Eg5

In Vitro

S-Trityl-L-cysteine binds to a unique pocket in the Eg5 motor domain formed by secondary structural elements (helix a2/loop L5/helix a3) ^[1] .
S-Trityl-L-cysteine (1-20 µM; for 72 h) could mediate cell apoptosis, as well as cell cycle arrest, in a dose-dependent manner. S-Trityl-L-cysteine-mediated apoptosis and cell cycle arrest were triggered by activation of the mitogen-activated protein kinase and nuclear factor kB signaling pathways ^[1] .
S-Trityl-L-cysteine induces mitotic arrest in HeLa cells (IC50 of 700 nM) with characteristic monoastral spindles ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 33.33 mg/mL ( 91.70 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7513 mL	13.7563 mL	27.5126 mL
5 mM	0.5503 mL	2.7513 mL	5.5025 mL
10 mM	0.2751 mL	1.3756 mL	2.7513 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (2.75 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (2.75 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (2.75 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

L-Cysteine, S-(triphenylmethyl)-

Alanine, 3-(tritylthio)-, L-

S-(Triphenylmethyl)-L-cysteine

S-Trityl-L-cysteine

NSC 83265

3-Tritylthio-L-alanine

Tritylthioalanine

S-Tritylcysteine

S-Trityl-(R)-cysteine

(2R)-2-Amino-3-[(triphenylmethyl)thio]propanoic acid

(2R)-2-Azaniumyl-3-tritylsulfanylpropanoate

(2R)-2-Amino-3-[(triphenylmethyl)sulfanyl]propanoic acid