[CAS NO. 28302-36-5] SodiumcopperchlorophyllinB

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PRODUCTS SPECIFICATIONS [28302-36-5]

Catalog

HY-B2226

Brand

MCE

CAS

28302-36-5

DESCRIPTION [28302-36-5]

Overview

MDL	MFCD00012149
Molecular Weight	738.13
Molecular Formula	C34H29CuN4Na3O7
SMILES	O=C(O[Na])CC1=C(C(C(O[Na])=O)=C(C)C2=CC3=[N]4C(C(C=O)=C3CC)=CC5=C(C=C)C(C)=C6[N-]75)[N-]2[Cu+2]47[N](C8=C6)=C1C(C8C)CCC(O[Na])=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]ACS Infect Dis. 2020 May 8;6(5):882-890.

Summary

Sodium copper chlorophyllin B exerts antiviral activities against Influenza virus and HIV with IC ₅₀ s of 50 to 100 μM for both of them.

IC50 & Target

IC50: 50 to 100 μM (Influenza virus), 50 to 100 μM (HIV) ^[1]

In Vitro

Sodium copper chlorophyllin B exhibits influenza virus adsorption at 200 µM (P<0.05). The IC ₅₀ and the 50% cytotoxic concentration (CC ₅₀ ) of Sodium copper chlorophyllin lay from 50 to 100 µM and 200 to 400 µM, respectively. Sodium copper chlorophyllin B also inhibits HIV adsorption at 2.5 mM (P<0.05). The IC ₅₀ and CC ₅₀ of Sodium copper chlorophyllin lay from 50 to 100 µM and 200 to 400 µM, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : 10 mg/mL ( 13.55 mM ; Need ultrasonic)

DMSO : 6.67 mg/mL ( 9.04 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3548 mL	6.7739 mL	13.5477 mL
5 mM	0.2710 mL	1.3548 mL	2.7095 mL
10 mM	0.1355 mL	0.6774 mL	1.3548 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 20 mg/mL (27.10 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.67 mg/mL (0.91 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.67 mg/mL (0.91 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.67 mg/mL (0.91 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Akiko Ito, et al. In Vitro Inhibition of Cytopathic Effect of Influenza Virus and Human Immunodeficiency Virus by Bamboo Leaf Extract Solution and Sodium Copper Chlorophyllin. Yonago Acta Med. 2016 Mar; 59(1): 61-65.

Synonyms

Cuprate(3-), [(7S,8S)-3-carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-17-formyl-7,8-dihydro-2,8,12-trimethyl-21H,23H-porphine-7-propanoato(5-)-κN²¹,κN²²,κN²³,κN²⁴]-, sodium (1:3), (SP-4-2)-

Copper, [dihydrogen 21-carboxy-14-ethyl-13-formyl-4,8,18-trimethyl-20-oxo-9-vinyl-3-phorbinepropionato(2-)]-, trisodium salt

Rhodine g, copper deriv., trisodium salt

Cuprate(3-), [(7S,8S)-3-carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-17-formyl-7,8-dihydro-2,8,12-trimethyl-21H,23H-porphine-7-propanoato(5-)-κN²¹,κN²²,κN²³,κN²⁴]-, trisodium, (SP-4-2)-

Sodium copper chlorophyllin

Chloron