[CAS NO. 28657-80-9] Cinoxacin
PRODUCTS SPECIFICATIONS [28657-80-9]
DESCRIPTION [28657-80-9]
Overview
| MDL | MFCD00056776 |
|---|---|
| Molecular Weight | 262.22 |
| Molecular Formula | C12H10N2O5 |
| SMILES | O=C(C1=NN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O |
1 Publications Citing Use of MCE
Summary
Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis [1] [2] .
IC50 & Target
|
Quinolone |
In Vitro
Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [2]
| Cell Line: | Gram-negative aerobic bacteria ( Escherichia coli , Proteus sp. etc.) |
| Concentration: | 0-200μg/mL approximately |
| Incubation Time: | 3-24 h |
| Result: | Inhibited basal cell proliferation (40% in FB-2 and 35% in WRO) at 10 μM, inhibited cell number (by 68% to 73%) at 40 and 60 μM). |
In Vivo
Cinoxacin (Oral administration, 1.7 g/kg, treated at 1 and 5 h postinfection) is effective in experimental bacterial infections in mice, with ED
50
values ranging from 8.1 to 58.6 mg/kg
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Indicated bacterial infected mice model [2] |
| Dosage: | 1.7 g/kg, treated at 1 and 5 h postinfection |
| Administration: | Oral administration |
| Result: | Displayed antibacterial activity with ED 50 values ranging from 8.1 to 58.6 mg/kg. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 8.33 mg/mL ( 31.77 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.8136 mL | 19.0680 mL | 38.1359 mL |
| 5 mM | 0.7627 mL | 3.8136 mL | 7.6272 mL |
| 10 mM | 0.3814 mL | 1.9068 mL | 3.8136 mL |
References
- [1] Scavone JM, et al. Cinoxacin: mechanism of action, spectrum of activity, pharmacokinetics, adverse reactions, and therapeutic indications. Pharmacotherapy. 1982 Sep-Oct;2(5):266-72.
- [2] W E Wick, et al. Compound 64716, a new synthetic antibacterial agent. Antimicrob Agents Chemother. 1973 Oct;4(4):415-20.
Synonyms