[CAS NO. 291778-77-3] AE-3763
PRODUCTS SPECIFICATIONS [291778-77-3]
DESCRIPTION [291778-77-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 549.54 |
| Molecular Formula | C23H34F3N5O7 |
| SMILES | O=C(O)CN1CCN(CC(N[C@H](C(N2[C@H](C(N[C@@H](C(C)C)C(C(F)(F)F)=O)=O)CCC2)=O)C(C)C)=O)C1=O |
Summary
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC 50 of 29 nM.
IC50 & Target
IC50: 29 nM (Human neutrophil elastase) [1]
In Vitro
AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED 50 : 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 16.67 mg/mL ( 30.33 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8197 mL | 9.0985 mL | 18.1970 mL |
| 5 mM | 0.3639 mL | 1.8197 mL | 3.6394 mL |
| 10 mM | 0.1820 mL | 0.9099 mL | 1.8197 mL |