[CAS NO. 2921-57-5] Methylprednisolone succinate

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PRODUCTS SPECIFICATIONS [2921-57-5]

Catalog

HY-B1900

Brand

MCE

CAS

2921-57-5

DESCRIPTION [2921-57-5]

Overview

MDL	-
Molecular Weight	474.54
Molecular Formula	C26H34O8
SMILES	C[C@@]12[C@](C(COC(CCC(O)=O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])C[C@H](C)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

For research use only. We do not sell to patients.

Summary

Methylprednisolone succinate is a synthetic glucocorticoid and widely used as an anti-inflammatory agent.

IC50 & Target

glucocorticoid receptor ^[1]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT04979650	Mazandaran University of Medical Sciences	Multiple Sclerosis, Relapsing-Remitting\|Magnetic Resonance Imaging\|Methylprednisolone	May 22, 2021	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 210.73 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1073 mL	10.5365 mL	21.0730 mL
5 mM	0.4215 mL	2.1073 mL	4.2146 mL
10 mM	0.2107 mL	1.0537 mL	2.1073 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6α,11β)-

Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-(hydrogen succinate)

Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-(H succinate)

Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-succinate

(6α,11β)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione

6α-Methylprednisolone hemisuccinate

6-Methylprednisolone hemisuccinate

6α-Methylprednisolone 21-succinate

Methylprednisolone succinate

Methylprednisolone 21-hemisuccinate

Methylprednisolone hemisuccinate