[CAS NO. 294648-66-1] ADAMTS-5-IN-2

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PRODUCTS SPECIFICATIONS [294648-66-1]

Catalog

HY-135710

Brand

MCE

CAS

294648-66-1

DESCRIPTION [294648-66-1]

Overview

MDL	-
Molecular Weight	309.39
Molecular Formula	C17H15N3OS
SMILES	O=C1NC2=C(C=C(CC)C=C2)C13SC(C4=CC=CC=C4)=NN3

For research use only. We do not sell to patients.

Summary

ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC ₅₀ value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis ^[1] ^[2] .

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References

[1] Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18(8):461-74.
[2] Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 2007, 17(20), 5630-5633.