[CAS NO. 30021-77-3] Cleistanthin B

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PRODUCTS SPECIFICATIONS [30021-77-3]

Catalog

HY-N9351

Brand

MCE

CAS

30021-77-3

DESCRIPTION [30021-77-3]

Overview

MDL	-
Molecular Weight	542.49
Molecular Formula	C27H26O12
SMILES	O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)=C2CO1

For research use only. We do not sell to patients.

Summary

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC ₅₀ of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo ^[1] ^[2] ^[3] ^[4] .

IC50 & Target

IC50: 6.51 µM (SARS-CoV-2) ^[1]

In Vitro

Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC ₅₀ of 6.51 µM ^[1] .
Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References

Synonyms

Naphtho[2,3-c]furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-4-(β-D-glucopyranosyloxy)-6,7-dimethoxy-

Cleistanthin B

9-(1,3-Benzodioxol-5-yl)-4-(β-D-glucopyranosyloxy)-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one

Diphyllin β-D-glucopyranoside

Diphyllin O-glucoside

Sheng Bai Xin

Diphyllin β-D-glucoside