[CAS NO. 301675-24-1] IRAK-4proteinkinaseinhibitor2
PRODUCTS SPECIFICATIONS [301675-24-1]
DESCRIPTION [301675-24-1]
Overview
| MDL | MFCD01006950 |
|---|---|
| Molecular Weight | 282.25 |
| Molecular Formula | C14H10N4O3 |
| SMILES | O=C(NC1=NC2=CC=CC=C2N1)C3=CC=CC([N+]([O-])=O)=C3 |
Summary
IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4) , with an IC 50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders [1] .
IC50 & Target
|
IRAK4 4 μM (IC 50 ) |
In Vitro
IRAK-4 protein kinase inhibitor 2 (compound 1) also inhibits IRAK-1, with an IC 50 of <10 μM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 10 mg/mL ( 35.43 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5430 mL | 17.7148 mL | 35.4296 mL |
| 5 mM | 0.7086 mL | 3.5430 mL | 7.0859 mL |
| 10 mM | 0.3543 mL | 1.7715 mL | 3.5430 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1 mg/mL (3.54 mM); Clear solution