[CAS NO. 301847-37-0] Org41841
PRODUCTS SPECIFICATIONS [301847-37-0]
DESCRIPTION [301847-37-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 402.53 |
| Molecular Formula | C19H22N4O2S2 |
| SMILES | O=C(C1=C(N)C2=C(C3=CC=CC(OC)=C3)N=C(SC)N=C2S1)NC(C)(C)C |
Summary
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor ( LHCGR ) and thyroid-stimulating hormone receptor ( TSHR ) with EC 50 s of 0.2 and 7.7 μM, respectively.
IC50 & Target
EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR) [1]
In Vitro
Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC 50 s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC 50 of 800 nM. M9 responds to Org41841 with an improved EC 50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 248.43 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4843 mL | 12.4214 mL | 24.8429 mL |
| 5 mM | 0.4969 mL | 2.4843 mL | 4.9686 mL |
| 10 mM | 0.2484 mL | 1.2421 mL | 2.4843 mL |