[CAS NO. 302939-48-6] KL201
PRODUCTS SPECIFICATIONS [302939-48-6]
DESCRIPTION [302939-48-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 388.28 |
| Molecular Formula | C17H14BrN3OS |
| SMILES | O=C(NC1=C(C2=C(CCCC2)S3)C3=NC=N1)C4=CC=CC=C4Br |
Summary
KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues [1] .
In Vitro
KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter
Per2-dLuc
. KL201 suppresses the intensity of
Per2-dLuc
reporter much more than that of
Bmal1-dLuc
, without affecting cellular viability
[1]
.
KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3
[1]
.
KL201 lengthened circadian period and suppressed the intensity of
Per2::Luc
knockin reporter in mouse lung primary explants
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 643.87 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5755 mL | 12.8773 mL | 25.7546 mL |
| 5 mM | 0.5151 mL | 2.5755 mL | 5.1509 mL |
| 10 mM | 0.2575 mL | 1.2877 mL | 2.5755 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.36 mM); Clear solution