[CAS NO. 30557-81-4] Bisabolangelone

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PRODUCTS SPECIFICATIONS [30557-81-4]

Catalog

HY-N4233

Brand

MCE

CAS

30557-81-4

DESCRIPTION [30557-81-4]

Overview

MDL	-
Molecular Weight	248.32
Molecular Formula	C15H20O3
SMILES	O=C1C=C(C)C[C@@]2([H])[C@]1([H])[C@@](C)(O)/C(O2)=C/C=C(C)\C

For research use only. We do not sell to patients.

Summary

Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities ^[1] ^[2] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 402.71 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0271 mL	20.1353 mL	40.2706 mL
5 mM	0.8054 mL	4.0271 mL	8.0541 mL
10 mM	0.4027 mL	2.0135 mL	4.0271 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4(2H)-Benzofuranone, 3,3a,7,7a-tetrahydro-3-hydroxy-3,6-dimethyl-2-(3-methyl-2-buten-1-ylidene)-, (2Z,3R,3aR,7aS)-

4(2H)-Benzofuranone, 3,3a,7,7a-tetrahydro-3-hydroxy-3,6-dimethyl-2-(3-methyl-2-butenylidene)-, [3S-(2Z,3α,3aβ,7aβ)]-

Bisabolangelone

4(2H)-Benzofuranone, 3,3a,7,7a-tetrahydro-3-hydroxy-3,6-dimethyl-2-(3-methyl-2-butenylidene)-, (2Z,3R,3aR,7aS)-

(2Z,3R,3aR,7aS)-3,3a,7,7a-Tetrahydro-3-hydroxy-3,6-dimethyl-2-(3-methyl-2-buten-1-ylidene)-4(2H)-benzofuranone

Angelikoreanol

Ligustilone

3-Hydroxy-3,6-dimethyl-2-(3-methylbut-2-enylidene)-3,3a,7,7a-tetrahydrobenzofuran-4(2H)-one

(+)-Bisabolangelone