[CAS NO. 30675-13-9] TCID
PRODUCTS SPECIFICATIONS [30675-13-9]
DESCRIPTION [30675-13-9]
Overview
| MDL | MFCD00239209 |
|---|---|
| Molecular Weight | 283.92 |
| Molecular Formula | C9H2Cl4O2 |
| SMILES | O=C1CC(C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl)=O |
Summary
IC50 & Target
IC50: 0.6 μM (UCH-L3) and 75 μM (UCH-L1) [1]
In Vitro
TCID (4,5,6,7-Tetrachloroindan-1,3-dione; compound 11) inhibits UCH-L1 with an IC
50
of 75 μM
[1]
.
TCID (10 μM; 1, 2 hours) diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 41.67 mg/mL ( 146.77 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5221 mL | 17.6106 mL | 35.2212 mL |
| 5 mM | 0.7044 mL | 3.5221 mL | 7.0442 mL |
| 10 mM | 0.3522 mL | 1.7611 mL | 3.5221 mL |
References
- [1] Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cellline. Chem Biol. 2003 Sep;10(9):837-46.
- [2] de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013;8(3):e58863.