[CAS NO. 30766-12-2] Methyl 5-hydroxypyridine-2-carboxylate

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PRODUCTS SPECIFICATIONS [30766-12-2]

Catalog

HY-W005963

Brand

MCE

CAS

30766-12-2

DESCRIPTION [30766-12-2]

Overview

MDL	MFCD05256426
Molecular Weight	153.14
Molecular Formula	C7H7NO3
SMILES	O=C(C1=NC=C(O)C=C1)OC

For research use only. We do not sell to patients.

Summary

Methyl 5-hydroxypyridine-2-carboxylate is a phenolic acid that can found in the stems of Mahonia fortune . Methyl 5-hydroxypyridine-2-carboxylate exhibits NO inhibitory effects in vitro ^[1] .

In Vitro

Methyl 5-hydroxypyridine-2-carboxylate (compound 2) inhibits NO in LPS-stimulated RAW264.7 and BV2 cells, with IC ₅₀ s of 115.67 and 118.80 μM, respectively ^[1] .
Methyl 5-hydroxypyridine-2-carboxylate (6.25-200 μM) does not exhibit any cytotoxic effect ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 326.50 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5300 mL	32.6499 mL	65.2997 mL
5 mM	1.3060 mL	6.5300 mL	13.0599 mL
10 mM	0.6530 mL	3.2650 mL	6.5300 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (16.32 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (16.32 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (16.32 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Liu L, et, al. Simultaneous characterisation of multiple Mahonia fortunei bioactive compounds in rat plasma by UPLC-MS/MS for application in pharmacokinetic studies and anti-inflammatory activity in vitro. J Pharm Biomed Anal. 2020 Feb 5;179:113013.

Synonyms

2-Pyridinecarboxylic acid, 5-hydroxy-, methyl ester

Picolinic acid, 5-hydroxy-, methyl ester

Methyl 5-hydroxy-2-pyridinecarboxylate

5-Hydroxy-2-pyridinecarboxylic acid methyl ester

6-Methoxycarbonylpyridin-3-ol

Methyl 5-hydroxypicolinate

5-Hydroxypicolinic acid methyl ester