[CAS NO. 309928-48-1] KL001

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PRODUCTS SPECIFICATIONS [309928-48-1]

Catalog

HY-108468

Brand

MCE

CAS

309928-48-1

DESCRIPTION [309928-48-1]

Overview

MDL	MFCD02086647
Molecular Weight	398.48
Molecular Formula	C21H22N2O4S
SMILES	CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O

For research use only. We do not sell to patients.

Summary

KL001 is a first-in-class cryptochrome ( CRY , a flavoproteins that are sensitive to blue light , and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis ^[1] ^[2] ^[3] .

In Vitro

KL001 (0.03-71 μM) causes circadian period lengthening and amplitude reduction in a dose-dependent manner in stable U2OS reporter cell lines harboring Bmal1-dLuc or Per2-dLuc ^[1] .
KL001 (2-8 μM; 18 h) represses glucagon-dependent induction of Pck1 and G6pc genes in a dose-dependent manner without affecting their basal expression in mouse primary hepatocytes ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL ( 12.55 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5095 mL	12.5477 mL	25.0954 mL
5 mM	0.5019 mL	2.5095 mL	5.0191 mL
10 mM	0.2510 mL	1.2548 mL	2.5095 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.25 mg/mL (3.14 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.25 mg/mL (3.14 mM); Suspended solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (3.14 mM); Clear solution

* All of the co-solvents are available by MCE.