[CAS NO. 312271-03-7] M2I-1

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PRODUCTS SPECIFICATIONS [312271-03-7]

Catalog

HY-100341

Brand

MCE

CAS

312271-03-7

DESCRIPTION [312271-03-7]

Overview

MDL	MFCD00469459
Molecular Weight	404.48
Molecular Formula	C19H24N4O4S
SMILES	O=C(/C(C(N1)=O)=C\C2=CC=C(N(CC(C)C)CC(C)C)C([N+]([O-])=O)=C2)NC1=S

For research use only. We do not sell to patients.

Summary

M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC) ^[1] .

IC50 & Target

Mad2 ^[1]

In Vitro

M2I-1 may not be sufficiently potent to fully inhibit SAC function in cells ^[1] .
M2I-1 weakens the SAC response, indicating that the compound might be active in cells. ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 32 mg/mL ( 79.11 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4723 mL	12.3616 mL	24.7231 mL
5 mM	0.4945 mL	2.4723 mL	4.9446 mL
10 mM	0.2472 mL	1.2362 mL	2.4723 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Johanna Kastl et al. Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. ACS Chem. Biol., 2015, 10 (7), pp 1661-1666.