[CAS NO. 31271-07-5] Gamma-Mangostin

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PRODUCTS SPECIFICATIONS [31271-07-5]

Catalog

HY-N1957

Brand

MCE

CAS

31271-07-5

DESCRIPTION [31271-07-5]

Overview

MDL	MFCD00951752
Molecular Weight	396.43
Molecular Formula	C23H24O6
SMILES	O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(O)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O

For research use only. We do not sell to patients.

Summary

Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana . Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization , it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer ^[2] . Gamma-Mangostin inhibits [3 ^H ] spiperone binding to cultured rat aortic myocytes ( IC ₅₀ =3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A ( IC ₅₀ =0.32 µM) ^[1] .

IC50 & Target

5-HT _2A Receptor

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 252.25 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5225 mL	12.6126 mL	25.2251 mL
5 mM	0.5045 mL	2.5225 mL	5.0450 mL
10 mM	0.2523 mL	1.2613 mL	2.5225 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-

9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-

Xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-

Mangostin, demethyl-

1,3,6,7-Tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

γ-Mangostin

Normangostin

1,3,6,7-Tetrahydroxy-2,8-bis(3,3-dimethylallyl)xanthone

7-O-Demethyl-α-mangostin

1,3,6,7-Tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one