[CAS NO. 312917-14-9] TCSJNK5a

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PRODUCTS SPECIFICATIONS [312917-14-9]

Catalog

HY-15881

Brand

MCE

CAS

312917-14-9

DESCRIPTION [312917-14-9]

Overview

MDL	MFCD01005305
Molecular Weight	332.42
Molecular Formula	C20H16N2OS
SMILES	O=C(C1=C2C=CC=CC2=CC=C1)NC3=C(C#N)C(CCCC4)=C4S3

For research use only. We do not sell to patients.

Summary

TCS JNK 5a is a potent JNK3 inhibitor with a pIC ₅₀ of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC ₅₀ of 6.5.

IC50 & Target

JNK3

6.7 (pIC ₅₀ )

JNK2

6.5 (pIC ₅₀ )

In Vitro

TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC ₅₀ <5.0) against all of them ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL ( 60.16 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0082 mL	15.0412 mL	30.0824 mL
5 mM	0.6016 mL	3.0082 mL	6.0165 mL
10 mM	0.3008 mL	1.5041 mL	3.0082 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2 mg/mL (6.02 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2 mg/mL (6.02 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2 mg/mL (6.02 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Angell RM, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.