[CAS NO. 32911-62-9]  Withanolide A

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PRODUCTS SPECIFICATIONS [32911-62-9]

Catalog
HY-N7028
Brand
MCE
CAS
32911-62-9

DESCRIPTION [32911-62-9]

Overview

MDL-
Molecular Weight470.60
Molecular FormulaC28H38O6
SMILESO=C1O[C@@]([H])([C@@](C)([C@H]2CC[C@]3([C@@]4([C@H]5[C@@H]([C@@](O)(CC=CC6=O)[C@]6([C@]4(CC[C@@]32C)[H])C)O5)[H])[H])O)CC(C)=C1C

For research use only. We do not sell to patients.

Summary

Withanolide A, isolated from the indian herbal drug Ashwagandha (root of Withania somnifera), could regenerate neurites and reconstruct synapses in severely damaged neurons [1] .


Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL ( 21.25 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1249 mL 10.6247 mL 21.2495 mL
5 mM 0.4250 mL 2.1249 mL 4.2499 mL
10 mM 0.2125 mL 1.0625 mL 2.1249 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: 1 mg/mL (2.12 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 1 mg/mL (2.12 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,20,22-trihydroxy-1-oxo-, δ-lactone, (5α,6α,7α,22R)-
5α-Ergosta-2,24-dien-26-oic acid, 6α,7α-epoxy-5,20,22-trihydroxy-1-oxo-, δ-lactone, (22R)-
6,7-Epoxy-1H-cyclopenta[a]phenanthrene, ergosta-2,24-dien-26-oic acid deriv.
5,20α-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide
Withaniol
Withanolide A
5α,20αF(R)-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide