[CAS NO. 330676-02-3] KH7
PRODUCTS SPECIFICATIONS [330676-02-3]
DESCRIPTION [330676-02-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 419.30 |
| Molecular Formula | C17H15BrN4O2S |
| SMILES | CC(SC1=NC2=CC=CC=C2N1)C(N/N=C/C3=CC(Br)=CC=C3O)=O |
4 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 3-10 μM (recombinant sAC t ) [1] .
In Vitro
KH7 (10 μM) blocks this capacitation-induced cAMP increase. At higher concentrations (50 μM), 5- to 10-fold above its IC50 but still selective for sAC relative to tmACs, KH7 resulted in a significant decrease in the basal cAMP accumulation in sperm regardless of the incubation medium
[1]
.
KH7 prevents the generation of CaSF
[2]
.
In the presence of KH7, the myocytes exerts a negative inotropic effect (NIE) of approximately 20%, suggesting that sAC is involved in the normal generation of basal cardiac contractility
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 250 mg/mL ( 596.23 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3849 mL | 11.9246 mL | 23.8493 mL |
| 5 mM | 0.4770 mL | 2.3849 mL | 4.7699 mL |
| 10 mM | 0.2385 mL | 1.1925 mL | 2.3849 mL |
References
- [1] Hess KC, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9(2):249-59.
- [2] Han J, et al. Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury. 4.658J Cell Mol Med. 2020 Mar 11.