[CAS NO. 331731-18-1]  Adalimumab

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PRODUCTS SPECIFICATIONS [331731-18-1]

Catalog
HY-P9908
Brand
MCE
CAS
331731-18-1

DESCRIPTION [331731-18-1]

Overview

MDL-
Molecular Weight145425.42
Molecular Formula-
SMILES[Adalimumab]

For research use only. We do not sell to patients.


Summary

Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor α ( TNF-α ).


IC50 & Target

TNF-α [1]


In Vitro

Treatment of HUVECs with Adalimumab for up to 12 hours shows no adverse effect on their cell viability, even with a 10-fold higher concentration of Adalimumab than used in this study [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

The elimination half-life (t 1/2 ) of Adalimumab is long (~20 days) [1] . The enriched fluorescent-labelled adalimumab is observed mainly in major Oil red O-positive lesions documenting good tissue penetration of the drug into the atherosclerotic plaque, without background fluorescence of the vessel wall after vehicle control injection into hypercholesterolemic Ldlr -/- mice [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT03955861 Belfast Health and Social Care Trust|British Medical Association|Psoriasis and Psoriatic Arthritis Alliance|Queen´s University, Belfast
Psoriatic Arthritis|Psoriasis|Enthesitis
February 14, 2019
NCT00595413 EMD Serono|Merck KGaA, Darmstadt, Germany
Rheumatoid Arthritis
September 2007 Phase 2
NCT00235859 Abbott|Eisai Limited
Rheumatoid Arthritis
July 2003 Phase 3

Appearance

Liquid


Shipping

Shipping with dry ice.


Storage

Please store the product under the recommended conditions in the Certificate of Analysis.