[CAS NO. 33889-69-9] Silychristin

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PRODUCTS SPECIFICATIONS [33889-69-9]

Catalog

HY-N0647

Brand

MCE

CAS

33889-69-9

DESCRIPTION [33889-69-9]

Overview

MDL	MFCD00883715
Molecular Weight	482.44
Molecular Formula	C25H22O10
SMILES	O=C1[C@H](O)[C@@H](C2=CC(O)=C(O[C@@H](C3=CC=C(O)C(OC)=C3)[C@@H]4CO)C4=C2)OC5=CC(O)=CC(O)=C15

For research use only. We do not sell to patients.

Summary

Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum , with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8 , and elicits a strong inhibition of T3 uptake with an IC ₅₀ of 110 nM ^[1] ^[2] .

IC50 & Target

MCT8 ^[2]

In Vitro

Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC ₅₀ of 110 nM in MCT8 overexpressing MDCK1-cells ^[2] .
Silychristin causes no cytotoxic for fibroblasts ^[3] .
Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent ^[3] .
Silychristin (12.5μM, 25μM) reduces the metalloproteinase-1 (MMP-1) level in cells ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[3]

Cell Line:	NHDF
Concentration:	6.5 μM,12.5 μM,25 μM,50 μM,75 μM
Incubation Time:	24 hours
Result:	Diminished UVA toxicity and reduced ROS generation in dose-dependent.

Cell Viability Assay ^[3]

Cell Line:	NHDF
Concentration:	12.5 μM, 25 μM
Incubation Time:
Result:	Reduced the metalloproteinase-1 (MMP-1) level in cells.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 207.28 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0728 mL	10.3640 mL	20.7280 mL
5 mM	0.4146 mL	2.0728 mL	4.1456 mL
10 mM	0.2073 mL	1.0364 mL	2.0728 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4H-1-Benzopyran-4-one, 2-[(2R,3S)-2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-

4H-1-Benzopyran-4-one, 2-[2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-, [2R-[2α(2R*,3S*),3β]]-

4-Chromanone, 2-[2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-3,5,7-trihydroxy-, (2S,3S)-(+)-

(2R,3R)-2-[(2R,3S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one

Silychristin

Silymarin II

Silicristin

Silycristin

Silichristin

Silychristin A

(+)-Silychristin