[CAS NO. 338967-87-6] Mdivi-1

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PRODUCTS SPECIFICATIONS [338967-87-6]

Catalog

HY-15886

Brand

MCE

CAS

338967-87-6

DESCRIPTION [338967-87-6]

Overview

MDL	MFCD00974506
Molecular Weight	353.22
Molecular Formula	C15H10Cl2N2O2S
SMILES	O=C1N(C2=C(Cl)C=C(Cl)C(OC)=C2)C(S)=NC3=C1C=CC=C3

For research use only. We do not sell to patients.

85 Publications Citing Use of MCE

Summary

Mdivi-1 is a selective dynamin-related protein 1 ( Drp1 ) inhibitor. Mdivi-1 is a mitochondrial division/ mitophagy inhibitor.

In Vitro

Mdivi-1 inhibits Dnm1 GTPase activity in a dose-dependent manner, with an estimated EC ₅₀ of 1-10 μM. Mdivi-1 increases the apparent K _0.5 for GTP, lowers the apparent V _max for GTP hydrolysis, and causes an increase in the Hill coefficient observed for GTP in the Dnm1 GTP hydrolysis reaction ^[1] . Cells treated with mdivi-1 display decreased cytochrome c release and a reduced rate of phosphatidylserine exposure on their surface following apoptosis induction, consistent with an inhibition of apoptosis and with previous studies using other strategies to compromise DRP1 activity ^[2] . Mdivi-1 results in apoptotic cell death in ischemic retina ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The mitochondrial division DRP, Dnm1, is the target of mdivi-1 in vivo. Mdivi-1 quantitatively blocks GMPPCP- dependent Dnm1 self-assembly in a concentration range similar to its effects on mitochondrial division in vivo ^[1] . Mdivi-1 (50 mg/kg, i.p.) significantly decreases GFAP protein expression in the normal mouse retina ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 160 mg/mL ( 452.98 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8311 mL	14.1555 mL	28.3110 mL
5 mM	0.5662 mL	2.8311 mL	5.6622 mL
10 mM	0.2831 mL	1.4155 mL	2.8311 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 17% Polyethylene glycol 12-hydroxystearate in saline

Solubility: 10 mg/mL (28.31 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 4 mg/mL (11.32 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 4 mg/mL (11.32 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 4 mg/mL (11.32 mM); Clear solution
5.

Add each solvent one by one: 0.5% CMC-Na /saline water

Solubility: 2.5 mg/mL (7.08 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.