[CAS NO. 34161-24-5] Fipexide

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PRODUCTS SPECIFICATIONS [34161-24-5]

Catalog

HY-B1124

Brand

MCE

CAS

34161-24-5

DESCRIPTION [34161-24-5]

Overview

MDL	MFCD00865385
Molecular Weight	388.84
Molecular Formula	C20H21ClN2O4
SMILES	ClC1=CC=C(OCC(N2CCN(CC3=CC=C(OCO4)C4=C3)CC2)=O)C=C1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Int J Mol Med. 2019 Oct 31;20(21):5448.

Summary

Fipexide, a parachloro-phenossiacetic acid derivative, is a nootropic drug. Fipexide reduces striatal adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide is used for senile dementia research ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 128.59 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5718 mL	12.8588 mL	25.7175 mL
5 mM	0.5144 mL	2.5718 mL	5.1435 mL
10 mM	0.2572 mL	1.2859 mL	2.5718 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (5.35 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] A Marino, et al. Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies. Pharmacol Res. Mar-Apr 1990;22(2):179-87.

Synonyms

Ethanone, 1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)-

Piperazine, 1-[(p-chlorophenoxy)acetyl]-4-piperonyl-

Piperazine, 1-(1,3-benzodioxol-5-ylmethyl)-4-[(4-chlorophenoxy)acetyl]-

1-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone

p-Chlorophenoxyacetylpiperonylpiperazide

Fipexide

1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine