[CAS NO. 345651-04-9] BVDV-IN-1

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PRODUCTS SPECIFICATIONS [345651-04-9]

Catalog

HY-131976

Brand

MCE

CAS

345651-04-9

DESCRIPTION [345651-04-9]

Overview

MDL	-
Molecular Weight	334.41
Molecular Formula	C20H22N4O
SMILES	OCCN1CCN(C2=C3C=CC=CC3=NC(C4=CC=CC=C4)=N2)CC1

For research use only. We do not sell to patients.

Summary

BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV) , with an EC ₅₀ of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC) ^[1] .

In Vitro

BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp) ^[1] .
BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 747.59 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9903 mL	14.9517 mL	29.9034 mL
5 mM	0.5981 mL	2.9903 mL	5.9807 mL
10 mM	0.2990 mL	1.4952 mL	2.9903 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.22 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.22 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.22 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Gabriela A Fernández, et al. Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus. Front Chem. 2020 Dec 10;8:590235.