[CAS NO. 35189-28-7] Norgestimate

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PRODUCTS SPECIFICATIONS [35189-28-7]

Catalog

HY-W013172

Brand

MCE

CAS

35189-28-7

DESCRIPTION [35189-28-7]

Overview

MDL	-
Molecular Weight	369.50
Molecular Formula	C23H31NO3
SMILES	C#C[C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])CCC4=C/C(CC[C@]4([H])[C@@]3([H])CC[C@]12CC)=N/O

For research use only. We do not sell to patients.

Summary

Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive ^[1] ^[2] .

In Vitro

Norgestimate is converted to at least two active metabolites: levonorgestrel 3-oxime (deacetylated norgestimate; norelgestromin) and levonorgestrel ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT04828824	University of Colorado, Denver	Contraception Behavior	June 18, 2021	Phase 4
NCT00554632	University of Vermont\|University of Vermont Medical Center	Venous Thrombosis	April 2003	Not Applicable
NCT02127593	Janssen Research & Development, LLC	Healthy	June 2013	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 338.29 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7064 mL	13.5318 mL	27.0636 mL
5 mM	0.5413 mL	2.7064 mL	5.4127 mL
10 mM	0.2706 mL	1.3532 mL	2.7064 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.08 mg/mL (5.63 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.63 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.63 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17α)-

Dexnorgestrel acetime

Norgestimate

ORF 10131

RWJ 10131

D 138

d-(17α)-17-Acetoxy-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one oxime