[CAS NO. 35404-50-3] Cyclocreatine
PRODUCTS SPECIFICATIONS [35404-50-3]
DESCRIPTION [35404-50-3]
Overview
| MDL | MFCD00134455 |
|---|---|
| Molecular Weight | 143.15 |
| Molecular Formula | C5H9N3O2 |
| SMILES | O=C(O)CN1CCNC1=N |
Summary
Cyclocreatine is a Creatine analogue and acts as a potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine crosses membranes, enters the brain, and can be phosphorylated and dephosphorylated by creatine kinases [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
1M HCl : 100 mg/mL ( 698.57 mM ; ultrasonic and adjust pH to 2 with HCl)
H 2 O : 12.5 mg/mL ( 87.32 mM ; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.9857 mL | 34.9284 mL | 69.8568 mL |
| 5 mM | 1.3971 mL | 6.9857 mL | 13.9714 mL |
| 10 mM | 0.6986 mL | 3.4928 mL | 6.9857 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (69.86 mM); Clear solution; Need ultrasonic and warming
References
- [1] Salwa A Elgebaly, et al. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion. Expert Rev Cardiovasc Ther. 2019 Sep;17(9):683-697.
- [2] Tyler K Ulland, et al. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. 2017 Aug 10;170(4):649-663.e13.