[CAS NO. 35897-92-8] Ligustroside

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PRODUCTS SPECIFICATIONS [35897-92-8]

Catalog

HY-N3383

Brand

MCE

CAS

35897-92-8

DESCRIPTION [35897-92-8]

Overview

MDL	-
Molecular Weight	524.51
Molecular Formula	C25H32O12
SMILES	OC(C=C1)=CC=C1CCOC(C[C@H]2/C([C@@H](OC=C2C(OC)=O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=C\C)=O

For research use only. We do not sell to patients.

Summary

Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages ^[1] ^[2] .

In Vitro

Ligstroside increases mRNA expression of SIRT1, CREB1, complex I, and GPx1 in SH-SY5Y-APP ₆₉₅ cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ligstroside (50 mg/kg; a supplemented diet for 6 months) protects against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female NMRI mice, aged 12 months ^[1]
Dosage:	50 mg/kg
Administration:	Received a supplemented diet for 6 months (equivalent to 6.25 mg/kg b.w.)
Result:	Showed improved spatial working memory; Restored brain ATP levels in aged mice and led to a significant life extension compared to aged control animals.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

References

Synonyms

2H-Pyran-4-acetic acid, 3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(4-hydroxyphenyl)ethyl ester, (2S,3E,4S)-

2H-Pyran-4-acetic acid, 3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(4-hydroxyphenyl)ethyl ester, [2S-(2α,3E,4β)]-

Ligstroside

Ligustroside