[CAS NO. 3682-04-0] Naringenin triacetate

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PRODUCTS SPECIFICATIONS [3682-04-0]

Catalog

HY-N3213

Brand

MCE

CAS

3682-04-0

DESCRIPTION [3682-04-0]

Overview

MDL	-
Molecular Weight	398.36
Molecular Formula	C21H18O8
SMILES	CC(OC1=C2C(O[C@H](C3=CC=C(OC(C)=O)C=C3)CC2=O)=CC(OC(C)=O)=C1)=O

For research use only. We do not sell to patients.

Summary

Naringenin triacetate is a flavonoid isolated from plant, exhibits a good binding affinity with multiple crystal structures of first bromodomain BRD4 (BRD4 BD1) ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 251.03 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5103 mL	12.5515 mL	25.1029 mL
5 mM	0.5021 mL	2.5103 mL	5.0206 mL
10 mM	0.2510 mL	1.2551 mL	2.5103 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Karthik Dhananjayan, Molecular Docking Study Characterization of Rare Flavonoids at the Nac-Binding Site of the First Bromodomain of BRD4 (BRD4 BD1). Journal of Cancer Research. Volume 2015.