[CAS NO. 370-86-5] FCCP

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PRODUCTS SPECIFICATIONS [370-86-5]

Catalog

HY-100410

Brand

MCE

CAS

370-86-5

DESCRIPTION [370-86-5]

Overview

MDL	MFCD00009699
Molecular Weight	254.17
Molecular Formula	C10H5F3N4O
SMILES	N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1

For research use only. We do not sell to patients.

26 Publications Citing Use of MCE

Summary

FCCP is an uncoupler of oxidative phosphorylation ( OXPHOS ) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation ^[1] .

In Vitro

FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability in K695sw cells. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells ^[1] . FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 393.44 mM )

Ethanol : ≥ 33.3 mg/mL ( 131.01 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9344 mL	19.6719 mL	39.3437 mL
5 mM	0.7869 mL	3.9344 mL	7.8687 mL
10 mM	0.3934 mL	1.9672 mL	3.9344 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (9.84 mM); Suspended solution; Need ultrasonic and warming
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (9.84 mM); Suspended solution; Need ultrasonic and warming
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.84 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Propanedinitrile, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-

Mesoxalonitrile, [p-(trifluoromethoxy)phenyl]hydrazone

Propanedinitrile, [[4-(trifluoromethoxy)phenyl]hydrazono]-

2-[2-[4-(Trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile

FCCP

Trifluoromethoxy carbonylcyanide phenylhydrazone

Carbonyl cyanide [p-(trifluoromethoxy)phenyl]hydrazone

Carbonyl cyanide [4-(trifluoromethoxy)phenyl]hydrazone

FCCCP

[[4-(Trifluoromethoxy)phenyl]hydrazono]malononitrile

2-[[4-(Trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile