[CAS NO. 3736-77-4] 2,2'-Anhydrouridine

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PRODUCTS SPECIFICATIONS [3736-77-4]

Catalog

HY-W012313

Brand

MCE

CAS

3736-77-4

DESCRIPTION [3736-77-4]

Overview

MDL	MFCD00004945
Molecular Weight	226.19
Molecular Formula	C9H10N2O5
SMILES	OC[C@@H](O1)[C@@H](O)[C@@](O2)([H])[C@]1([H])N(C2=N3)C=CC3=O

For research use only. We do not sell to patients.

Summary

2,2'-Anhydrouridine is used for anticancer and antiviral research ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 110.53 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4211 mL	22.1053 mL	44.2106 mL
5 mM	0.8842 mL	4.4211 mL	8.8421 mL
10 mM	0.4421 mL	2.2105 mL	4.4211 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (11.05 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Drabikowska AK, et al. Inhibitor properties of some 5-substituted uracil acyclonucleosides, and 2,2'-anhydrouridines versus uridine phosphorylase from E. coli and mammalian sources. Biochem Pharmacol. 1987 Dec 1;36(23):4125-8.

Synonyms

6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidin-6-one, 2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-, (2R,3R,3aS,9aR)-

6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidin-6-one, 2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-, [2R-(2α,3β,3aβ,9aβ)]-

6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidin-6-one, 2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-, stereoisomer

6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidin-6-one, 2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-

(2R,3R,3aS,9aR)-2,3,3a,9a-Tetrahydro-3-hydroxy-2-(hydroxymethyl)-6H-furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidin-6-one

O²,2′-Cyclouridine

2,2′-O-Cyclouridine

2,2′-Anhydro-1-β-D-arabino-furanosyluracil

2,2′-Anhydrouridine

2,2′-Anhydro-N¹-(β-D-arabinofuranosyl)uracil

2,2′-Anhydro(1-β-D-arabinofuranosyl)uracil

β-D-2′,2-O-Cycloarabinouridine

O²,2′-Anhydrouridine

NSC 157148