[CAS NO. 3785-24-8] Nepodin
PRODUCTS SPECIFICATIONS [3785-24-8]
DESCRIPTION [3785-24-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 216.23 |
| Molecular Formula | C13H12O3 |
| SMILES | CC(C1=C(C)C=C2C=CC=C(O)C2=C1O)=O |
Summary
IC50 & Target
|
Plasmodium |
In Vitro
Nepodin (Musizin) exhibits significant IC
50
values that are 0.74 and 0.79 μg/ml against
P. falciparum
chloroquine-sensitive (3D7) and
P. falciparum
chloroquine-resistant (S20), respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | C57BL/KsJ-db/db mice [2] |
| Dosage: | 2 mg/kg; 10 mg/kg |
| Administration: | Orally administration; 2-10 mg/kg; 4 weeks |
| Result: | Had antihyperglycemic potential and improved insulin resistance. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL ( 578.09 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.6247 mL | 23.1235 mL | 46.2471 mL |
| 5 mM | 0.9249 mL | 4.6247 mL | 9.2494 mL |
| 10 mM | 0.4625 mL | 2.3124 mL | 4.6247 mL |
References
Synonyms