[CAS NO. 381168-77-0] ML367
PRODUCTS SPECIFICATIONS [381168-77-0]
DESCRIPTION [381168-77-0]
Overview
| MDL | MFCD01897460 |
|---|---|
| Molecular Weight | 334.32 |
| Molecular Formula | C19H12F2N4 |
| SMILES | FC1=CC(NC2=NC(C3=CC=NC=C3)=NC4=CC=CC=C42)=CC=C1F |
Summary
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 ( ATAD5 ) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation [1] .
IC50 & Target
ATAD5 [1]
In Vitro
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | HEK293T cells |
| Concentration: | 0-40 μM in the presence or absence of 20 μM 5-Furd |
| Incubation Time: | 16 hours |
| Result: | Inhibited the increased ATAD5 protein levels induced by 5-Furd. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 125 mg/mL ( 373.89 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9911 mL | 14.9557 mL | 29.9115 mL |
| 5 mM | 0.5982 mL | 2.9911 mL | 5.9823 mL |
| 10 mM | 0.2991 mL | 1.4956 mL | 2.9911 mL |