[CAS NO. 38183-03-8] 7,8-Dihydroxyflavone

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [38183-03-8]

Catalog

HY-W013372

Brand

MCE

CAS

38183-03-8

DESCRIPTION [38183-03-8]

Overview

MDL	MFCD00006836
Molecular Weight	254.24
Molecular Formula	C15H10O4
SMILES	O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC=C13

For research use only. We do not sell to patients.

10 Publications Citing Use of MCE

Summary

7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases ^[1] .

IC50 & Target

TrkB ^[1]

In Vitro

7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease ^[1] .

Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 393.33 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9333 mL	19.6665 mL	39.3329 mL
5 mM	0.7867 mL	3.9333 mL	7.8666 mL
10 mM	0.3933 mL	1.9666 mL	3.9333 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50.

Synonyms

4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-

Flavone, 7,8-dihydroxy-

7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

7,8-Dihydroxyflavone

7,8-Dihydroxy-2-phenyl-4H-chromen-4-one