[CAS NO. 3877-86-9] Cucurbitacin D

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PRODUCTS SPECIFICATIONS [3877-86-9]

Catalog

HY-N1986

Brand

MCE

CAS

3877-86-9

DESCRIPTION [3877-86-9]

Overview

MDL	MFCD01711333
Molecular Weight	516.67
Molecular Formula	C30H44O7
SMILES	C[C@@]([C@@](CC=C(C(C)1C)[C@@]2([H])C[C@H](O)C1=O)([H])[C@@]2(C)C3=O)(C[C@@H](O)[C@]4([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)[C@@]4(C3)C

For research use only. We do not sell to patients.

Summary

Cucurbitacin D is an active component in Trichosanthes kirilowii , disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf , Cdk6 , pAkt) maturation without induction of the heat shock response. Anti-cancer activity ^[1] .

IC50 & Target

HSP90

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 110 mg/mL ( 212.90 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9355 mL	9.6774 mL	19.3547 mL
5 mM	0.3871 mL	1.9355 mL	3.8709 mL
10 mM	0.1935 mL	0.9677 mL	1.9355 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.75 mg/mL (5.32 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.75 mg/mL (5.32 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Hall JA, et al. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. J Nat Prod. 2015 Apr 24;78(4):873-9.

Synonyms

19-Norlanosta-5,23-diene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (2β,9β,10α,16α,23E)-

19-Nor-9β,10α-lanosta-5,23-diene-3,11,22-trione, 2β,16α,20,25-tetrahydroxy-9-methyl-

(2β,9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione

Elatericin A

Cucurbitacin D

NSC 521776

Cucurbitacine D

Elatericine A

NSC 308606

(+)-Cucurbitacin D