[CAS NO. 39011-92-2] Specnuezhenide
PRODUCTS SPECIFICATIONS [39011-92-2]
DESCRIPTION [39011-92-2]
Overview
| MDL | MFCD20274720 |
|---|---|
| Molecular Weight | 686.66 |
| Molecular Formula | C31H42O17 |
| SMILES | C/C=C([C@@H]1O[C@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CO)\[C@@H](C(C(OC)=O)=CO1)CC(OC[C@H]([C@H]([C@H](O)[C@H]3O)O)O[C@H]3OCCC4=CC=C(O)C=C4)=O |
1 Publications Citing Use of MCE
Summary
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum . Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) [1] .
In Vitro
Specnuezhenide (0.2-5.0 μg/mL) significantly decreases the mRNA expression of VEGFA induced by CoCl2 as a dose-dependent manner in ARPE-19 cells [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 250 mg/mL ( 364.08 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.4563 mL | 7.2816 mL | 14.5632 mL |
| 5 mM | 0.2913 mL | 1.4563 mL | 2.9126 mL |
| 10 mM | 0.1456 mL | 0.7282 mL | 1.4563 mL |
References
- [1] Ma C, et al. Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.Front Pharmacol. 2018 Jun 28;9:700.
- [2] Wu J, et al. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.Molecules. 2016 Dec 21;21(12). pii: E1756.