[CAS NO. 39711-79-0] TRPM8 agonist WS-3

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PRODUCTS SPECIFICATIONS [39711-79-0]

Catalog

HY-W014325

Brand

MCE

CAS

39711-79-0

DESCRIPTION [39711-79-0]

Overview

MDL	MFCD00130071
Molecular Weight	211.34
Molecular Formula	C13H25NO
SMILES	CC(C)C1CCC(C)CC1C(NCC)=O

For research use only. We do not sell to patients.

Summary

TRPM8 agonist WS-3 is an agonist of TRPM8 with an EC ₅₀ of 3.7 μM.

IC50 & Target

EC50: 3.7 μM (TRPM8) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 473.17 mM )

H ₂ O : 1 mg/mL ( 4.73 mM ; ultrasonic and heat to 60°C)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7317 mL	23.6586 mL	47.3171 mL
5 mM	0.9463 mL	4.7317 mL	9.4634 mL
10 mM	0.4732 mL	2.3659 mL	4.7317 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (11.83 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.83 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.83 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Behrendt HJ, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45.

Synonyms

Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)-

N-Ethyl-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

N-Ethyl-p-menthane-3-carboxamide

WS 3 (amide)

WS 3

Ethyl menthane carboxamide

Cooling Sensate WS 3

FEMA 3455

N-Ethyl-p-menthanecarboxamide