[CAS NO. 4097-22-7] 2',3'-Dideoxyadenosine

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PRODUCTS SPECIFICATIONS [4097-22-7]

Catalog

HY-W013441

Brand

MCE

CAS

4097-22-7

DESCRIPTION [4097-22-7]

Overview

MDL	MFCD00010534
Molecular Weight	235.24
Molecular Formula	C10H13N5O2
SMILES	OC[C@@H]1CC[C@H](N2C(N=CN=C3N)=C3N=C2)O1

For research use only. We do not sell to patients.

Summary

2',3'-Dideoxyadenosine is an inhibitor of HIV replication ^[1] . Antiretroviral activity ^[1] . Antiviral efficacy ^[1] .

IC50 & Target

HIV-1

HIV-2

In Vitro

2',3'-Dideoxyadenosine inhibits HIV-1 and simian immunodeficiency virus (SIV) in MT-4 cells with EC ₅₀ s of 5.27 and 5.3 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in human T-lymphocyte CEM cells with EC ₅₀ s of 4 μM and 8 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in Molt 4/C8 cells with EC ₅₀ s of 4 μM and 5.5 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in C8166 cells with EC ₅₀ s of 17 μM and 22 μM, respectively. 2',3'-Dideoxyadenosine inhibits murine sarcoma virus (MSV) in C3H/3T3 cells with an EC ₅₀ of 24 μM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 425.10 mM ; Need ultrasonic)

H ₂ O : 100 mg/mL ( 425.10 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2510 mL	21.2549 mL	42.5098 mL
5 mM	0.8502 mL	4.2510 mL	8.5020 mL
10 mM	0.4251 mL	2.1255 mL	4.2510 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 14.29 mg/mL (60.75 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (8.84 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (8.84 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (8.84 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Balzarini J, et al. Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus. FEBS Lett. 1997 Jun 30;410(2-3):324-8.

Synonyms

Adenosine, 2′,3′-dideoxy-

2′,3′-Dideoxyadenosine

Dideoxyadenosine

NSC 98700

NQZ-047