[CAS NO. 41468-25-1] Pyridoxal 5'-phosphate monohydrate
PRODUCTS SPECIFICATIONS [41468-25-1]
DESCRIPTION [41468-25-1]
Overview
| MDL | MFCD00149414 |
|---|---|
| Molecular Weight | 265.16 |
| Molecular Formula | C8H12NO7P |
| SMILES | O=CC1=C(O)C(C)=NC=C1COP(O)(O)=O.[H]O[H] |
1 Publications Citing Use of MCE
Summary
Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6 , is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP) [1] [2] .
IC50 & Target
IC50: active form of vitamin B6 [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 5 mg/mL ( 18.86 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7713 mL | 18.8565 mL | 37.7131 mL |
| 5 mM | 0.7543 mL | 3.7713 mL | 7.5426 mL |
| 10 mM | 0.3771 mL | 1.8857 mL | 3.7713 mL |
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1.
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Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 0.5 mg/mL (1.89 mM); Clear solution
References
- [1] Allen GF, et al. Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states.J Neurochem. 2010 Jul;114(1):87-96.
- [2] Calderón-Ospina CA, et al. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin.CNS Neurosci Ther. 2020 Jan;26(1):5-13.
Synonyms