[CAS NO. 41544-24-5] Tromantadine hydrochloride

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PRODUCTS SPECIFICATIONS [41544-24-5]

Catalog

HY-U00124B

Brand

MCE

CAS

41544-24-5

DESCRIPTION [41544-24-5]

Overview

MDL	-
Molecular Weight	316.87
Molecular Formula	C16H29ClN2O2
SMILES	[H]Cl.O=C(COCCN(C)C)NC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]COVID. 2022, 2(11), 1551-1563.

Summary

Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication ^[1] .

IC50 & Target

HSV-1

HSV-2

In Vitro

Treatment of the cells with 10 to 50μg of Tromantadine reduces HSV-induced cytopathic effect. Treatment with 100 to 500μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL ( 197.24 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1559 mL	15.7793 mL	31.5587 mL
5 mM	0.6312 mL	3.1559 mL	6.3117 mL
10 mM	0.3156 mL	1.5779 mL	3.1559 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.56 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.56 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.56 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Rosenthal KS, et al. Tromantadine: inhibitor of early and late events in herpes simplex virus replication. Antimicrob Agents Chemother. 1982 Dec;22(6):1031-6.

Synonyms

Acetamide, 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.1^3,7]dec-1-yl-, hydrochloride (1:1)

Acetamide, 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.1^3,7]dec-1-yl-, monohydrochloride

Tromantadine hydrochloride