[CAS NO. 4192-90-9] Trilobatin

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [4192-90-9]

Catalog

HY-N4100

Brand

MCE

CAS

4192-90-9

DESCRIPTION [4192-90-9]

Overview

MDL	-
Molecular Weight	436.41
Molecular Formula	C21H24O10
SMILES	OC(C=C1)=CC=C1CCC(C2=C(C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2O)O)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Phytomedicine. 2022 Jul;101:154113.

Summary

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd ^[1] , Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope ^[2] . Neuroprotective effects ^[1] . Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells ^[3] .

IC50 & Target

HIV-1

SGLT1

SGLT2

In Vitro

Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 286.43 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2914 mL	11.4571 mL	22.9142 mL
5 mM	0.4583 mL	2.2914 mL	4.5828 mL
10 mM	0.2291 mL	1.1457 mL	2.2914 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1-Propanone, 1-[4-(β-D-glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-

p-Phlorizin

1-[4-(β-D-Glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone

p-Phloridzin

Prunin dihydrochalcone

Trilobatin

Phloretin 4′-glucoside

Phloretine-4′-glucoside

Phloretin 4′-β-D-glucoside

Phloretin-4′-O-β-D-glucopyranoside