[CAS NO. 420841-84-5] H2L5765834
PRODUCTS SPECIFICATIONS [420841-84-5]
DESCRIPTION [420841-84-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 404.33 |
| Molecular Formula | C21H12N2O7 |
| SMILES | O=C(C1=CC2=C(C(N(C3=CC=CC(OC4=CC=C([N+]([O-])=O)C=C4)=C3)C2=O)=O)C=C1)O |
Summary
H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA 1 , LPA 3 , and LPA 5 , with IC 50 s of 94, 752, and 463 nM respectively [1] .
IC50 & Target
|
LPA 1 Receptor 94 nM (IC 50 ) |
LPA 3 Receptor 752 nM (IC 50 ) |
LPA 5 Receptor 463 nM (IC 50 ) |
In Vitro
In Vivo
H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 618.31 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4732 mL | 12.3661 mL | 24.7323 mL |
| 5 mM | 0.4946 mL | 2.4732 mL | 4.9465 mL |
| 10 mM | 0.2473 mL | 1.2366 mL | 2.4732 mL |
References
- [1] Williams JR, et, al. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19; 284(25): 17304-19.
- [2] Bae GH, et, al. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. Exp Mol Med. 2017 Dec 8; 49(12): e407.