[CAS NO. 425629-94-3] PfDHODH-IN-2
PRODUCTS SPECIFICATIONS [425629-94-3]
DESCRIPTION [425629-94-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 297.76 |
| Molecular Formula | C13H12ClNO3S |
| SMILES | O=C(C1=C(NC2=CC=C(Cl)C=C2)SCC1=O)OCC |
Summary
PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH) inhibitor with an IC 50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria [1] .
IC50 & Target
IC50: 1.113 µM (PfDHODH)
IC50: >50 µM ( hDHODH)
[1]
In Vitro
Malaria is a global parasitic infectious disease caused by
Plasmodium
parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality
[1]
.
PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC
50
=1.113 µM) over hDHODH (IC
50
>50 µM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of
P. falciparum
with IC
50
values of both >20 µM, respectively in whole cell assays
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 12.5 mg/mL ( 41.98 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3584 mL | 16.7920 mL | 33.5841 mL |
| 5 mM | 0.6717 mL | 3.3584 mL | 6.7168 mL |
| 10 mM | 0.3358 mL | 1.6792 mL | 3.3584 mL |