[CAS NO. 434-13-9] Lithocholicacid
PRODUCTS SPECIFICATIONS [434-13-9]
DESCRIPTION [434-13-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 376.57 |
| Molecular Formula | C24H40O3 |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])CC3)C)([H])CC1 |
7 Publications Citing Use of MCE
Summary
Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity. Target: Others Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. It has been implicated in human and experimental animal carcinogenesis. Preliminary in vitro research suggests that LCA selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations.
IC50 & Target
|
Microbial Metabolite |
Human Endogenous Metabolite |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 663.89 mM ; Need ultrasonic)
Ethanol : 10 mg/mL ( 26.56 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6555 mL | 13.2777 mL | 26.5555 mL |
| 5 mM | 0.5311 mL | 2.6555 mL | 5.3111 mL |
| 10 mM | 0.2656 mL | 1.3278 mL | 2.6555 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (5.52 mM); Clear solution
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.52 mM); Clear solution
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3.
-
4.
Add each solvent one by one: 10% EtOH >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 1 mg/mL (2.66 mM); Clear solution
-
5.
Add each solvent one by one: 10% EtOH >> 90% corn oil
Solubility: ≥ 1 mg/mL (2.66 mM); Clear solution
References
- [1] Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993. 329(1): p. 21-6.
- [2] Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260.
- [3] Goldberg, A.A., et al., Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011. 2(10): p. 761-82.
- [4] Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53(12): p. 2698-707.
Synonyms