[CAS NO. 4431-01-0] Ligustilide

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PRODUCTS SPECIFICATIONS [4431-01-0]

Catalog

HY-N0401

Brand

MCE

CAS

4431-01-0

DESCRIPTION [4431-01-0]

Overview

MDL	MFCD01861511
Molecular Weight	190.24
Molecular Formula	C12H14O2
SMILES	O=C1O/C(C2=C1C=CCC2)=C\CCC

For research use only. We do not sell to patients.

Summary

Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects ^[1] ^[2] ^[3] .

In Vitro

Pretreatment with Ligustilide (1 μM, 5 μM, 15 μM) significantly improves cell viability. The apoptosis rate in glutamate-induced PC12 cells is 13.39%, and decreased in the presence of Ligustilide (1 μM, 5 μM, 15 μM) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca ²⁺ induced by glutamate are significantly reduced by Ligustilide. Pretreatment Ligustilide could decrease the release of cytochrome C from mitochondria, down-regulate Caspase-3 protein expression and up-regulate Bcl-2/Bax ratio, thereby protects PC12 cells from apoptosis ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Liquid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

* The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 525.65 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2565 mL	26.2826 mL	52.5652 mL
5 mM	1.0513 mL	5.2565 mL	10.5130 mL
10 mM	0.5257 mL	2.6283 mL	5.2565 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-

1,5-Cyclohexadiene-1-carboxylic acid, 2-(1-hydroxy-1-pentenyl)-, γ-lactone

Ligustilide

Phthalide, 3-butylidene-4,5-dihydro-

3-Butylidene-4,5-dihydro-1(3H)-isobenzofuranone

3-Butylidene-4,5-dihydrophthalide

3-Butylidene-4,5-dihydro-2-benzofuran-1-one