[CAS NO. 448906-42-1] ITE
PRODUCTS SPECIFICATIONS [448906-42-1]
DESCRIPTION [448906-42-1]
Overview
| MDL | MFCD06411597 |
|---|---|
| Molecular Weight | 286.31 |
| Molecular Formula | C14H10N2O3S |
| SMILES | O=C(C1=CSC(C(C2=CNC3=C2C=CC=C3)=O)=N1)OC |
5 Publications Citing Use of MCE
Summary
ITE is a potent endogenous agonist of aryl hydrocarbon receptor ( AhR ), binding directly to AHR , with a K i of 3 nM. ITE also has immunosuppressive activity.
IC50 & Target
Ki: 3 nM (AhR) [1]
In Vitro
ITE is an endogenous agonist of AhR, binding directly to AHR, with a K i of 3 nM [1] . ITE (0.03-30 mg/mL) decreases the antigen-specific T-cell proliferative responses [2] . ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 µM, but shows no effect at 0.01-5 µM. ITE does not affect cell cycle progress of HPAECs at 10 and 20 µM, or induce expression of cleaved caspase-3 protein in HPAECs at 20 µM. In addition, ITE (20 µM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 41 mg/mL ( 143.20 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.4927 mL | 17.4636 mL | 34.9272 mL |
| 5 mM | 0.6985 mL | 3.4927 mL | 6.9854 mL |
| 10 mM | 0.3493 mL | 1.7464 mL | 3.4927 mL |
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1.
Add each solvent one by one: 17% Polyethylene glycol 12-hydroxystearate in saline
Solubility: 10 mg/mL (34.93 mM); Suspended solution; Need ultrasonic
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.67 mg/mL (9.33 mM); Clear solution
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3.
References
- [1] Song J, et al. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14694-9.
- [2] Nugent LF, et al. ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity. Invest Ophthalmol Vis Sci. 2013 Nov 13;54(12):7463-9.
- [3] Pang LP, et al. ITE inhibits growth of human pulmonary artery endothelial cells. Exp Lung Res. 2017 Oct;43(8):283-292.
Synonyms