[CAS NO. 452967-14-5] IR415
PRODUCTS SPECIFICATIONS [452967-14-5]
DESCRIPTION [452967-14-5]
Overview
| MDL | MFCD00238878 |
|---|---|
| Molecular Weight | 296.34 |
| Molecular Formula | C13H14F2N4S |
| SMILES | S=C(NCCCN1C=CN=C1)NC2=CC=C(F)C=C2F |
Summary
IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx ( K d =2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease [1] . HBx: hepatitis B virus X protein.
IC50 & Target
Kd: 2 nM (IR415-HBx interaction) [1]
In Vitro
Hepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of viral genes
[1]
.
IR415 (50-200 μM) has a dose-dependent inhibitory effect on HBx, with a minimal effective concentration of 50 μM in HepG2/GFP-shRNA line transfected with HBx
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 421.81 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3745 mL | 16.8725 mL | 33.7450 mL |
| 5 mM | 0.6749 mL | 3.3745 mL | 6.7490 mL |
| 10 mM | 0.3375 mL | 1.6873 mL | 3.3745 mL |