[CAS NO. 458-36-6] Coniferaldehyde

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PRODUCTS SPECIFICATIONS [458-36-6]

Catalog

HY-N2535

Brand

MCE

CAS

458-36-6

DESCRIPTION [458-36-6]

Overview

MDL	MFCD00075811
Molecular Weight	178.18
Molecular Formula	C10H10O3
SMILES	O=C/C=C/C1=CC=C(O)C(OC)=C1

For research use only. We do not sell to patients.

Summary

Coniferaldehyde (Ferulaldehyde) is an effective inducer of heme oxygenase-1 ( HO-1 ). Coniferaldehyde exerts anti-inflammatory properties in response to LPS. Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 561.23 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6123 mL	28.0615 mL	56.1230 mL
5 mM	1.1225 mL	5.6123 mL	11.2246 mL
10 mM	0.5612 mL	2.8062 mL	5.6123 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (5.61 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (5.61 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (5.61 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kim KM, et al. Coniferaldehyde inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Environ Toxicol Pharmacol. 2016 Dec;48:85-93.

Synonyms

2-Propenal, 3-(4-hydroxy-3-methoxyphenyl)-

Cinnamaldehyde, 4-hydroxy-3-methoxy-

3-(4-Hydroxy-3-methoxyphenyl)-2-propenal

Coniferaldehyde

Ferulaldehyde

p-Coniferaldehyde

4-Hydroxy-3-methoxycinnamaldehyde

Coniferyl aldehyde

3-Methoxy-4-hydroxycinnamaldehyde

3-(4-Hydroxy-3-methoxyphenyl)acrolein

Ferulyl aldehyde

2-Methoxy-4-(3-oxo-1-propenyl)phenol

4-Hydroxy-3-methoxyzimtaldehyde

3-(4-Hydroxy-3-methoxyphenyl)propenal

Ferulic aldehyde