[CAS NO. 469-36-3] 24-Methylenecycloartanyl ferulate

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PRODUCTS SPECIFICATIONS [469-36-3]

Catalog

HY-N8122

Brand

MCE

CAS

469-36-3

DESCRIPTION [469-36-3]

Overview

MDL	-
Molecular Weight	616.91
Molecular Formula	C41H60O4
SMILES	CC1(C)[C@@H](OC(/C=C/C2=CC=C(O)C(OC)=C2)=O)CC[C@]3(C4)C54CC[C@]6(C)[C@@H]([C@H](C)CCC(C(C)C)=C)CC[C@](C)6[C@]5([H])CC[C@@]13[H]

For research use only. We do not sell to patients.

Summary

24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor ( EC ₅₀ = 33.3μM) ^[1] .

IC50 & Target

Akt1

33.3 μM (EC ₅₀ )

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 12.5 mg/mL ( 20.26 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6210 mL	8.1049 mL	16.2098 mL
5 mM	0.3242 mL	1.6210 mL	3.2420 mL
10 mM	0.1621 mL	0.8105 mL	1.6210 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (2.03 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Heon Woong Kim, et al. 24-Methylenecycloartanyl ferulate, a major compound of γ-oryzanol, promotes parvin-beta expression through an interaction with peroxisome proliferator-activated receptor-gamma 2 in human breast cancer cells. Biochem Biophys Res Comm